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Meridia
MERIDIA (sibutramine hydrochloride monohydrate) is an orally administered agent for the treatment of obesity. Chemically, the active ingredient is a racemic mixture of the (+) and (-) enantiomers of cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-α (2-methylpropyl)-, hydrochloride, monohydrate, and has an empirical formula of C17H29Cl2NO. Its molecular weight is 334.33. The structural formula is shown below:
Sibutramine hydrochloride monohydrate is a white to cream crystalline powder with a solubility of 2.9 mg/mL in pH 5.2 water. Its octanol: water partition coefficient is 30.9 at pH 5.0.
Each MERIDIA capsule contains 5 mg, 10 mg, and 15 mg of sibutramine hydrochloride monohydrate. It also contains as inactive ingredients: lactose monohydrate, NF; microcrystalline cellulose, NF; colloidal silicon dioxide, NF; and magnesium stearate, NF in a hard-gelatin capsule [which contains titanium dioxide, USP; gelatin; FD&C Blue No. 2 (5- and 10-mg capsules only); D&C Yellow No. 10 (5- and 15-mg capsules only), and other inactive ingredients].
Meridia is targeted for the seriously obese and not for those who are looking to lose a few pounds. Linda Mayer, director of communications at Knoll, states, “This is serious medicine, and it is only for certain people. In the past, there has been too much emphasis on cosmetic use of obesity drugs. We’re focusing on the health benefits. It is not about how you look but instead about how your health will improve if you lose weight.”
This drug is recommended only for obese patients with an initial body mass index (BMI) greater or equal to 30 ( a person who is 5�5″ and weight 180 pounds), or a BMI of 27 in the presence of other risk factors, such as diabetes, hypertension, arthritis, sleep apnea, or dyslipidemia (low HDL and high triglycerides) (Fentress, 33-34). BMI is a measurement based on height and weight as they relate to body fat. It can be used to determine how much risk people have of developing certain health problems because of their weight. Someone with a BMI of 27 is approximately 20% overweight.
Meridia (Sibutramine) is a drug for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines. Sibutramine is classified as a Schedule IV controlled substance in the United States. Meridia (Sibutramine) acts by increasing serotonin and norepinephrine levels in the brain. The serotonergic action, in particular, is thought to influence appetite.
Meridia (Sibutramine) is a neurotransmitter reuptake inhibitor that helps enhance satiety by inhibiting the reuptake of serotonin (by 53%), norepinephrine (by 54%), and dopamine (by 16%).
Meridia (sibutramine) affects chemicals in the body that are related to weight maintenance. Meridia is used together with diet and exercise to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure. Meridia may also be used for other purposes not listed in this medication guide.
Meridia belongs to a group of drugs, known as monoamine reuptake inhibitors. The medication interacts with the chemicals in the body which control weight. Meridia is commonly used in the treatment of obesity. The medicine may also be used for other purposes.
In the fall of 1997, fenfluramine (the fen half of the popular fen-phen drug combination) and Redux (dexfenfluramine) were recalled after the drugs were linked to potentially fatal heart valve abnormalities. In November of 1997, only a few months after the withdrawal of fenfluramine and Redux, the Federal Drug Administration (FDA) approved Meridia. Meridia is a class of drug known as monoamine (serotonin and norepinephrine) re-uptake inhibitors. It falls in the same class of many anti- depressants such as Prozac. Serotonin is a chemical released in the brain after you have eaten a meal, which makes you feel full. When a nerve impulse reaches the end of the nerve (the nerve terminal), the impulse causes the release of chemicals called neurotransmitters. The neurotransmitters are released in the space between the two adjacent neurons, this region is called the synaptic cleft. Usually once the neurotransmitters have bound to their receptors (the neurotransmitter and the receptor fit like a lock and a key) on the adjacent nerve, transport proteins work to reabsorb the extra neurotransmitter back into the nerve terminal so that they can be reused. However, Meridia acts to inhibit the reabsorption of serotonin so the that signal lasts longer, thus giving the sensation that you are full for a longer period of time. This method is thought to effectively reduce the caloric intake of an obese individual due to appetite suppression.
Although Meridia and fenfluramine have similar mechanisms of action (they both affect serotonin), fenfluramine boosts the levels of serotonin into the blood stream. This increase in the levels of serotonin is believed to have caused the heart valve damage seen in some patients. Essentially the difference between the two drugs is that Meridia is more localized, whereas fenfluramine has a systemic effect. Because of this difference, researchers believe that Meridia will not be linked with heart valve damage. As stated by Lawrence Cheskin, M.D., director of the Johns Hopkins Weight Management Center in Baltimore, “Meridia bypasses the heart and acts directly on the brain’s appetite control center. Meridia maintains serotonin levels in the brain, thereby curbing some carbohydrate cravings (Brietzke, 90)”. Carbohydrates boost levels of serotonin in the brain, and this impacts appetite and mood so when your brain is running low on the chemical, it tells you to refuel. Meridia keeps serotonin levels elevated, short-circuiting these mentally fueled cravings. The drug also boosts adrenaline levels, curbing overall appetite.
Buy Meridia Online – potent Anti Obesity Pill
BMI (Body Mass Index) of 30 or more is an alarm signal. This puts you in a high health risk category and you should do something about it immediately.
Meridia diet pills are designed for use by highly obese people who need to loose weight to avoid complications. Obesity is directly linked to numerous ailments, some of which can lead to premature death.
Meridia works on a simple principle. It tricks the brain into issuing a ‘feel full’ signal which means that you do not eat. When this happens, your calorie intake is reduced and the fat deposits in your body are utilized to provide energy for daily chores.
During clinical trials it was observed that more than 45% of the users who took Meridia daily for more than six months were able to loose weight effectively and also keep it off for up to two years once the Meridia therapy was terminated. This makes this weight loss drug highly recommendable as it not only helps you loose weight but also keeps it off once you go off the drug.
Users who are targeting weight loss around the waist and thigh region are recommend to use Meridia. These regions show a high tendency in weight accumulation and it takes quite an effort to get rid of this excess fat.
Meridia comprises of sibutramine HCl monohydrate which is an active anti obesity agent. It has been in use since mid nineties and has been extensively researched by medical scientists.
Meridia has FDA approval and classified as a controlled substance in the US. This is due to its habit forming properties. Some users try to abuse the drug and this leads to complications. If you intend to use Meridia for long term, you must discuss this fact with your doctor and ensure means to avoid getting dependant on the drug.
Due to its powerful anti obesity properties, Meridia must always be taken under expert supervision. Overdosing and off-label use can lead to complications. Meridia must not be given to users who suffer from seizures or stroke. Pregnant and nursing women must be cautious in its use.
This drug may cause high blood pressure or increase the heart rate. Thus it is necessary to keep a constant watch on your vital signs especially during the initial phase while using Meridia. Some users may develop allergic reactions which are generally mild and go away as your body develops resistance to the drug.
Being an adult only drug, Meridia must be kept away from children.
This is a prescription drug and must always be purchased against a valid prescription written according to the users needs. Never share your prescription with anyone.
All weight loss diet pills show best results when they compliment healthy eating and regular physical exercise. These two elements serve you well through out your life and keep you away from health risks. In the long run they are more useful than drugs to reduce excess fat. Nevertheless if situation does get out of hand, Meridia is always there to help you.
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Generic Meridia is commonly known and used as an appetite suppressant. When used along with your diet plan, it helps reduce weight at faster pace. Sibutramine is the generic or chemical name of meridia. Sibutramine is also known as sibutramide hydrochloride monohydrate is a oral medication used in the treatment for obesity. Sibutramine is classified as a Schedule IV controlled substance in the United States.
Generic Meridia or Sibutramine is recommended for people who are overweight and also suffering from other health problems like high blood pressure, diabetes etc. To loose weight it is necessary to consume generic meridia with a low calorie diet. What does generic meridia do? It increases the level of serotonin, dopamine, and norepinephrine in the nervous system. The increase in serotonin triggers serotonergic action in the nervous system which is believed to influence appetite.
Generic Meridia is widely promoted as a weight loss pill across the globe. It comes in different strengths (5mg, 10mg and 15mg) to suit the user’s requirement. When consumed as per the instructions mentioned on the label, you can loose anywhere between 3lbs to 25 lbs in a year. But the fact remains that you need to carry a healthy lifestyle while taking meridia to get the desired results.
Generic Meridia is initially prescribed for 4 weeks, during this time the patient is regularly checked for any signs of weight loss or side effects. Also, his blood pressure and heart rate is monitored regularly. A 10mg dose is to be consumed daily (preferably in the morning), if this is not good enough then your doctor may increase your dose to 15mg (daily) after 4 weeks. Sometime if the drug is not suiting the individual then blood pressure and heart rate can increase. A weight loss of about 4lb is estimated during the course of this medication. If the desired result in terms of weight loss is not achieved, either stop this medication or increase the dosage as per your doctor’s advice.
Generic Meridia is not for someone who just wants to shed few pounds. We must understand that it is a serious medication and is recommended for people who are really overweight. In today’s age of fashion, people use weight loss drugs as cosmetics than using it for the real cause i.e. health. We should not misinterpret the primary use of Generic Meridia which is to improve your health and not to make you look like a slim.
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What is Generic Meridia (Sibutramine)?
Generic Meridia (Sibutramine) affects chemicals in the body that are related to weight maintenance.
Generic Meridia (Sibutramine) is used as a short-term supplement to diet and exercise in the treatment of obesity.
Generic Meridia (Sibutramine) may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about Generic Meridia (Sibutramine)?
Generic Meridia (Sibutramine) has been reported to cause increased blood pressure in some patients. It is important to have your blood pressure and pulse monitored regularly while taking Generic Meridia (Sibutramine).
Use caution when driving, operating machinery, or performing other hazardous activities. Generic Meridia (Sibutramine) may cause dizziness, difficulty concentrating, or restlessness. If you experience these effects, avoid hazardous activities. Do not take any other prescription or over-the-counter medicines without first talking to your doctor, especially weight-loss products, tryptophan (L-tryptophan, 5-HTP), decongestants, antidepressants, cough suppressants, lithium (Eskalith, Lithobid, Lithonate, others), and migraine medicines.
What is Generic Meridia (Sibutramine)?
Generic Meridia (Sibutramine) affects chemicals in the body that are related to weight maintenance.
Generic Meridia (Sibutramine) is used as a short-term supplement to diet and exercise in the treatment of obesity.
Generic Meridia (Sibutramine) may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about Generic Meridia (Sibutramine)?
Generic Meridia (Sibutramine) has been reported to cause increased blood pressure in some patients. It is important to have your blood pressure and pulse monitored regularly while taking Generic Meridia (Sibutramine).
Use caution when driving, operating machinery, or performing other hazardous activities. Generic Meridia (Sibutramine) may cause dizziness, difficulty concentrating, or restlessness. If you experience these effects, avoid hazardous activities. Do not take any other prescription or over-the-counter medicines without first talking to your doctor, especially weight-loss products, tryptophan (L-tryptophan, 5-HTP), decongestants, antidepressants, cough suppressants, lithium (Eskalith, Lithobid, Lithonate, others), and migraine medicines.
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Generic Meridia or Sibutramine is recommended for people who are overweight and also suffering from other health problems like high blood pressure, diabetes etc. To loose weight it is necessary to consume generic meridia with a low calorie diet. What does generic meridia do? It increases the level of serotonin, dopamine, and norepinephrine in the nervous system. The increase in serotonin triggers serotonergic action in the nervous system which is believed to influence appetite.
Generic Meridia is widely promoted as a weight loss pill across the globe. It comes in different strengths (5mg, 10mg and 15mg) to suit the user’s requirement. When consumed as per the instructions mentioned on the label, you can loose anywhere between 3lbs to 25 lbs in a year. But the fact remains that you need to carry a healthy lifestyle while taking meridia to get the desired results.
Generic Meridia is initially prescribed for 4 weeks, during this time the patient is regularly checked for any signs of weight loss or side effects. Also, his blood pressure and heart rate is monitored regularly. A 10mg dose is to be consumed daily (preferably in the morning), if this is not good enough then your doctor may increase your dose to 15mg (daily) after 4 weeks. Sometime if the drug is not suiting the individual then blood pressure and heart rate can increase. A weight loss of about 4lb is estimated during the course of this medication. If the desired result in terms of weight loss is not achieved, either stop this medication or increase the dosage as per your doctor’s advice.
Generic Meridia is not for someone who just wants to shed few pounds. We must understand that it is a serious medication and is recommended for people who are really overweight. In today’s age of fashion, people use weight loss drugs as cosmetics than using it for the real cause i.e. health. We should not misinterpret the primary use of Generic Meridia which is to improve your health and not to make you look like a slim.